TRAINING

Find out how functional genomics and epigenomic approaches uncover transcriptional dependencies in advanced prostate cancer. The speaker will highlight how his team's discovery of a CDK7- dependent MED1 phospho-switch that controls androgen receptor (AR) recruitment and oncogenic transcription at super-enhancers, and recent work using an epigenetics-focused CRISPR screen and genome-wide chromatin profiling to identify NSD2 as an essential component of the AR–FOXA1 neoenhanceosome that establishes the tumor-specific AR cistrome.